TABLE 2.
Motor Symptom Severity of Patients (N = 8) Before and After Treatment as a Function of Stimulation (On and Off) in the Off-Medication Condition
| STN+GPi+ | STN+GPi+ | |||
|---|---|---|---|---|
| Baselinea | 6 mob | 1 yr | ||
| Total UPDRS-III | 43.8 ± 13.5 | 24.1 ± 10.1a | 24.8 ± 10.0a | |
| STN-stim contralateral limb | Tremor | 6.0 ± 5.0 | 1.0 ± 1.5a | 0.1 ± 0.4a |
| Rigidity | 4.5 ± 1.3 | 2.8 ± 2.1 | 3.6 ± 1.2 | |
| Bradykinesia | 11.6 ± 5.6 | 5.1 ± 2.0a | 5.6 ± 2.7a | |
| GPi-stim contralateral limb | Tremor | 1.1 ± 2.1 | 0.4 ± 0.7 | 0.3 ± 0.5 |
| Rigidity | 3.6 ± 1.8 | 3.5 ± 2.0 | 3.5 ± 1.1 | |
| Bradykinesia | 9.6 ± 4.4 | 5.0 ± 3.1a | 4.4 ± 4.0a | |
| Axial signs | Total axial score | 9.1 ± 4.5 | 7.4 ± 3.5 | 8.3 ± 4.7 |
| Arise from chair | 1.0 ± 1.1 | 0.3 ± 0.5 | 0.3 ± 0.5 | |
| Gait | 1.5 ± 0.8 | 0.9 ± 0.6 | 1.0 ± 0.9 | |
| Postural stability | 1.1 ± 1.0 | 0.6 ± 0.5 | 0.8 ± 1.2 | |
| Posture | 1.5 ± 1.1 | 1.5 ± 1.3 | 1.6 ± 0.9 | |
| TUG | 20.7 ± 10.8 | 12.2 ± 3.1a | 13.9 ± 4.1 | |
| GFQ | Total score | 13.6 ± 10.2 | 6.6 ± 6.7 | 4.9 ± 3.4a |
| Gait score | 11.5 ± 8.6 | 5.9 ± 6.8 | 3.5 ± 2.9a | |
| Falls score | 2.1 ± 2.7 | 0.7 ± 1.1 | 1.4 ± 2.1 | |
| STN–GPi– | STN–GP–- | |||
| Baselinea | 6 mob | 1 yr | ||
| Total UPDRS-III | 43.8 ± 13.5 | 41.1 ± 10.3 | 46.8 ± 13.6 | |
| STN-stim contralateral limb | Tremor | 6.0 ± 5.0 | 5.4 ± 4.9 | 6.0 ± 4.6 |
| Rigidity | 4.5 ± 1.3 | 5.1 ± 1.2 | 5.4 ± 1.6 | |
| Bradykinesia | 11.6 ± 5.6 | 9.9 ± 3.7 | 11.9 ± 4.2 | |
| GPi-stim contralateral limb | Tremor | 1.1 ± 2.1 | 0.5 ± 0.8 | 0.9 ± 2.1 |
| Rigidity | 3.6 ± 1.8 | 4.1 ± 1.4 | 4.5 ± 1.4 | |
| Bradykinesia | 9.6 ± 4.4 | 8.1 ± 4.1 | 9.1 ± 4.4 | |
| Axial signs | Total axial score | 9.1 ± 4.5 | 9.4 ± 3.9 | 11.6 ± 4.6b |
| Arise from chair | 1.0 ± 1.1 | 0.5 ± 0.5 | 1.0 ± 0.9 | |
| Gait | 1.5 ± 0.8 | 1.5 ± 0.8 | 1.4 ± 0.7 | |
| Postural stability | 1.1 ± 1.0 | 0.8 ± 1.0 | 0.9 ± 1.0 | |
| Posture | 1.5 ± 1.1 | 1.6 ± 1.1 | 1.8 ± 0.7 | |
| TUG | 20.7 ± 10.8 | 14.9 ± 4.9 | 20.7 ± 9.2 | |
GFQ, Gait and Fall Questionnaire; GPi, globus pallidus interna; GPi-STN–, without stimulation; GPi+STN+, with unilateral STN and contralateral GPi stimulation; med off, without medication; STN, the subthalamic nucleus; TUG, Timed Up-and-Go Test; UPDRS, Unified Parkinson Disease Rating Scale.
a,bThe letters a and b indicate a significant difference (P < .05) between 2 time points (Wilcoxon signed-rank test).
Values are presented as mean ± SD.