Table 2. Optical coherence tomography studies evaluating anatomical parameters for detecting ischemia in non-left main coronary artery disease.
| Study | No. of patients/no. of lesions | Intermediate lesion definition | FFR cut off value | AUC (MLA/MLD) | OCT MLA, mm2/MLD mm | Sensitivity (MLA/MLD) |
Specificity (MLA/MLD) |
PPV (MLA/MLD) |
NPV (MLA/MLD) |
Diagnostic accuracy (MLA/MLD) |
Comment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gonzalo et al. (15) | 56/61 | 40% to 70% DS by QCA | 0.80 | 0.74/0.73 | 1.95/1.34 | 82/82 | 63/67 | 66/68 | 80/81 | 72/73 | Simultaneously compared with IVUS and better efficiency for RVD <3 mm |
| Shiono et al. (16) | 59/62 | >30% by visual assessment | 0.75 | 0.90/0.92 | 1.91/1.35 | 93.5/90.3 | 77.4/80.6 | 80.6/84.4 | 92.3/84.6 | 85.4/85.5 | Additionally, assessed percent area stenosis |
| Pawlowski et al. (17) | 48/71 | 40% to 70% DS by visual assessment | 0.80 | 0.91/0.90 | 2.05/1.28 | 75/71 | 90/84 | 70.6/68.5 | 92.6/90.6 | 87/87 | No relationship between FFR and lesion length |
| Reith et al. (18) | 46/62 (diabetic patients) | 40% to 70% DS by QCA | 0.80 | 0.81/0.81 | 1.59/1.31 | 75.8/87.9 | 79.3/72.4 | 80.6/78.4 | 74.2/84 | 77.4/80.6 | FFR predicted FCT ≤80 µm |
| Zafar et al. (19) | 30/41 | >30% DS by visual assessment | 0.80 | 0.80/0.76 | 1.62/1.23 | 70/70 | 97/87 | 89/64 | 91/90 | −/− | High efficiency for RVD <3 mm |
| Burzotta et al. (20) | 40/40 | 30% to 80% DS by visual assessment | 0.8 | 0.83 | 2.5 | 64 | 93 | 85 | AS% and plaque ulceration independently predicted FFR |
FFR, fractional flow reserve; AUC, area under the curve; MLA, minimal lumen area; MLD, minimal lumen diameter; OCT, optical coherence tomography; PPV, positive predictive value; NPV, negative predictive value; IVUS, intravascular ultrasound; DS, diameter stenosis; QCA, quantitative coronary angiography; RVD, reference vessel diameter.