Figure 3.
Integrated OCT and NIRAF imaging of a TCFA. (A) Coronary angiogram of the left anterior descending artery; (B) NIRAF map identifying a focal region of elevated NIRAF in the ostial left anterior descending artery, and below, the three-dimensional cutaway rendering demonstrating the highest NIRAF spot appears focally within a lipid pool; (C,D,E) OCT and NIRAF cross sections from sites in the ostial left anterior descending artery revealing subclinical fibrous cap rupture. Key: *, guide-wire shadowing artifact; OCT showing white luminal thrombus (arrow), plaque rupture (R), thrombus (T). [Images adapted with permission from Ughi et al. (19)]. OCT, optical coherence tomography; NIRAF, near-infrared autofluorescence; TCFA, thin-cap fibroatheroma.