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. 2020 Oct;10(5):1245–1255. doi: 10.21037/cdt-20-545

Figure 4.

Figure 4

LncRNA HIF1A-AS1 interacted with miR-138 and suppressed its expression. (A) The expression levels of miR-675, miR-29b, miR-200a and miR-138 were measured by quantitative RT-PCR in normal myocardial tissue and myocardium infected by CVB3 for 7 days. (B) Knockdown of HIF1A-AS1 upregulated miR-138 expression evaluated by quantitative RT-PCR. (C) Predicted binding sites of lncRNA HIF1A-AS1 with miR-138 sequence. (D) Transfection with miR-138 mimics abolished the luciferase activity of pGL3 vector containing HIF1A-AS1 fragment (chr11: 2,016,882-chr11: 2,016,889). Data are mean ± SEM and representative of three separate experiments. *, P<0.05. siCTR, control siRNA.