Table 3.

Mechanism of Action of Protease Inhibitors

Name of Drug	Mechanism of Action on Cultured Parasite
Leupeptin	Causes the food vacuole to swell and fill with dark-staining material, blocks the processing of hemoglobin, Inhibits lysis of erythrocyte membranes
Anti-pain	Inhibits lysis of erythrocyte membranes
E-64	Causes the food vacuole to swell and fill with dark-staining material, inhibits lysis of parasitophorous vacuole, Blocks the processing of hemoglobin
Chymostatin (serine protease inhibitor)	Inhibits erythrocyte invasion