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. 2020 Nov 10;14:4815–4824. doi: 10.2147/DDDT.S276704

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© 2020 Chen et al.

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Mean plasma concentration–time profiles of venlafaxine (A) and O-desmethylvenlafaxine (B) after an oral administration of venlafaxine (20 mg/kg) to rats in the presence and absence of vonoprazan (5 and 20 mg/kg) (mean ± S.D., n=6); (1) Low-dose group was pretreat with vonoprazan (5 mg/kg, oral); (2) High-dose group was pretreat with vonoprazan (20 mg/kg, oral); (3) Control group was administered by venlafaxine (20 mg/kg, oral).