Table 4.
Mean Pharmacokinetic Parameters of Venlafaxine (VEN) After Oral Administration (20 mg/kg) to Rats in the Presence and Absence of Vonoprazan (5 and 20 mg/kg)
| Parameters | VEN | VEN + Vonoprazan | |
|---|---|---|---|
| 5 mg/kg | 20 mg/kg | ||
| AUC(0-t) (µg·L−1·h−1) | 260.40 ± 101.62 | 688.80 ± 160.61* | 1,905.03 ± 548.19* |
| AUC (0-∞) (µg·L−1·h−1) | 260.91 ± 101.43 | 693.96 ± 162.74* | 1,922.61 ± 565.66* |
| MRT(0-t) (h) | 2.09 ± 0.18 | 2.44 ± 0.30 | 3.28 ± 0.52* |
| MRT (0-∞) (h) | 2.12 ± 0.17 | 2.52 ± 0.43 | 3.36 ± 0.56* |
| t1/2z (h) | 1.39 ± 0.32 | 1.48 ± 0.46 | 1.28 ± 0.53 |
| Tmax (h) | 0.70 ± 0.21 | 0.95 ± 0.37 | 2.60 ± 0.55* |
| Vz/F (L·kg−1) | 187.22 ± 129.65 | 62.08 ± 15.41 | 19.93 ± 7.19* |
| CLz/F (L·h−1·kg−1) | 87.60 ± 37.78 | 30.02 ± 6.51* | 11.50 ± 4.80* |
| Cmax (µg·L−1) | 127.38 ± 41.53 | 261.43 ± 109.51* | 525.11 ± 114.59* |
Notes: n = 6 per group; data are expressed as mean ± SD. *Significantly different from control, P < 0.05.
Abbreviations: AUC, area under the plasma concentration–time curve; CL, plasma clearance; Cmax, maximum plasma concentration; MRT, mean residence time; t1/2, half-life; Tmax, time taken to reach maximum plasma level.