Table 5.
Mean Pharmacokinetic Parameters of O-Desmethylvenlafaxine (ODV) After Oral Administration of Venlafaxine (VEN; 20mg/kg) to Rats in the Presence and Absence of Vonoprazan (5 and 20 mg/kg)
| Parameters | VEN | VEN + Vonoprazan | |
|---|---|---|---|
| 5 mg/kg | 20 mg/kg | ||
| AUC(0-t) (µg·L−1·h−1) | 155.32 ± 36.65 | 220.80 ± 31.51* | 469.33 ± 68.58* |
| AUC(0-∞) (µg·L−1·h−1) | 160.95 ± 43.45 | 224.59 ± 31.70* | 491.64 ± 79.81* |
| MRT(0-t) (h) | 2.82 ± 0.55 | 3.08 ± 0.48 | 3.92 ± 0.38* |
| MRT(0-∞) (h) | 3.20 ± 1.16 | 3.28 ± 0.49 | 4.44 ± 0.52 |
| t1/2z (h) | 2.05 ± 1.05 | 2.01 ± 0.36 | 2.43 ± 0.75 |
| Tmax (h) | 0.75 ± 0.18 | 0.95 ± 0.37 | 2.60 ± 0.55* |
| Vz/F (L·kg−1) | 373.67 ± 170.49 | 259.92 ± 41.47 | 141.68 ± 30.36* |
| CLz/F (L·h−1·kg−1) | 131.82 ± 35.47 | 90.37 ± 11.76 | 41.74 ± 8.16* |
| Cmax (µg·L−1) | 58.10 ± 14.09 | 69.72 ± 30.05 | 109.35 ± 13.42* |
| MR | 1.64±0.52 | 3.06±0.29* | 3.84±0.69* |
Notes: n = 6 per group; data are expressed as mean ± SD; *Significantly different from control, P < 0.05.*MR ODV =AUC VEN/AUC ODV.15
Abbreviations: AUC, area under the plasma concentration–time curve; CL, plasma clearance; Cmax, maximum plasma concentration; MRT, mean residence time; t1/2, half-life; Tmax, time taken to reach maximum plasma level.