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. 2020 Nov 10;14:4801–4813. doi: 10.2147/DDDT.S274812

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© 2020 Wang et al.

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Acacetin alleviated TBHP-induced inflammation and ECM degradation. The NPCs were treated with TBHP (50 µM) alone or combination with acacetin (0.3 µM, 1 µM) for 24 hours. (A, B) Relative mRNA expression levels of iNOS and COX-2 were determined by qPCR. (C) Protein expression levels of iNOS and COX-2 were evaluated using Western blotting. (D, E, F, G, H) Relative mRNA expression levels of aggrecan, collagen II, MMP13, MMP9 and MMP3 were evaluated using qPCR. (I) Protein expression levels of aggrecan, collagen II, MMP13, MMP9 and MMP3 were determined using Western blotting. Data are represented as the mean ± SD. n=3. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.