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. 2020 Nov 10;14:4801–4813. doi: 10.2147/DDDT.S274812

Figure 4.

Figure 4

Acacetin activated the Nrf2 pathway and inhibited TBHP-induced activation of the MAPK pathway. (A) The NPCs were pretreated with acacetin (0.3 µM, 1 µM) for two hours and then treated with TBHP (50 µM) for another 24 hours. The intranuclear protein content of Nrf2 was evaluated using Western blotting. (B) The NPCs were pretreated with acacetin (0.3 µM, 1 µM) for two hours and then treated with TBHP (50 µM) for another 24 hours. Protein expression levels of p38, p-p38, ERK, p-ERK, JNK, and p-JNK were evaluated using Western blotting. The experiment was repeated three times.