Table 3. Characteristics of included studies from China.
| ## | Author | Year | Institution | City | Study cohort | Tissue type | Technique | Total PTC | BRAF+ | BRAF rate (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Gu LQ (69) | 2009 | Shanghai Jiaotong University School of Medicine + Yueqing People’s Hospital | Shanghai, Zhejiang | n/s | FFPE | PCR | 123 | 42 | 34 |
| 2 | Guan H (70) | 2009 | multisite | Shenyang, Shanghai, Binzhou, Heze, Qingdao | 1990–2007 | FFPE | Seq | 1032 | 639 | 62 |
| 3 | Feng L (71) | 2011 | Dalian Medical University | Dalian | 2006–2007 | FFPE | IHC | 70 | 42 | 60 |
| 4 | Wang W (72) | 2012 | The First Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou | 2006–2008 | FFPE | PCR + Seq | 208 | 115 | 55 |
| 5 | Xia T (73) | 2012 | Affiliated Tumor Hospital of Tianjin Medical University | Tianjin | 2011 | Fresh frozen | PCR + Seq | 110 | 69 | 63 |
| 6 | Zheng X (74) | 2012 | Tianjin Medical University Cancer Institute and Hospital | Tianjin | 1995–2000 | FFPE | PCR | 512 | 263 | 51 |
| 7 | Zhou YL (75) | 2012 | First Affiliated Hospital of Wenzhou Medical College | Wenzhou | 2010–2011 | FNA | PCR | 100 | 31 | 31 |
| 8 | Gong RX (76) | 2013 | West China Hospital, Sichuan University | Chengdu | 2009–2011 | FFPE | PCR | 187 | 119 | 64 |
| 9 | Huang Y (77) | 2013 | The First Affiliated Hospital, Sun Yat-Sen University | Guangzhou | 2008–2010 | Fresh frozen | PCR | 69 | 33 | 48 |
| 10 | Guo HQ (78) | 2014 | Chinese Academy of Medical Science | Beijing | 2010–2011 | FNA | PCR | 63 | 41 | 65 |
| 11 | He G (79) | 2014 | West China Hospital, Sichuan University | Sichuan | 2009–2011 | FFPE | PCR | 187 | 119 | 64 |
| 12 | Huang FJ (80) | 2014 | Shanghai Jiaotong University | Shanghai | 2009–2011 | Fresh frozen | Seq | 214 | 147 | 69 |
| 13 | Liu S (81) | 2014 | Xian Jiaotong University Health Science Center | Xian | 2011–2014 | FNA | Pyroseq | 132 | 80 | 61 |
| 14 | Liu X (82) | 2014 | multisite | Shanghai, Shenyang, Qingdao, Heza, Binzhou | n/s | FFPE | PCR | 408 | 250 | 61 |
| 15 | Lu H (83) | 2014 | Chinese Academy of Medical Science | Beijing | 2010–2012 | FFPE | PCR + Seq | 292 | 190 | 65 |
| 16 | Shao H (84) | 2014 | Heze Municipal Hospital | Shandong | 2002–2006 | FFPE | Seq | 200 | 133 | 67 |
| 17 | Wei X (85) | 2014 | Tianjin Cancer Hospital | Tianjin | 2011–2013 | FFPE | IHC | 369 | 297 | 80 |
| 18 | Lu J (86) | 2015 | Peking Union Medical College Hospital (PUMCH) | Beijing | 2013–2014 | FFPE | ARMS PCR + qPCR | 150 | 121 | 81 |
| 19 | Qiu T (87) | 2015 | Chinese Academy of Medical Sciences | Beijing | 2010–2014 | FFPE | IHC + Seq | 127 | 102 | 80 |
| 20 | Shi C (88) | 2015 | Second Affiliated Hospital of Harbin Medical University | Harbin | n/s | FFPE | qPCR | 126 | 87 | 69 |
| 21 | Sun J (89) | 2015 | Peking Union Medical College Hospital (PUMCH) | Beijing | 2010–2012 | FFPE | IHC + Seq | 556 | 419 | 75 |
| 22 | Yang LB (90) | 2015 | West China Hospital | Sichuan | 2013–2014 | FFPE | Seq | 543 | 170 | 31 |
| 23 | Yu L (91) | 2015 | Hangzhou First Peoples Hospital | Hangzhou | 2012–2013 | Fresh frozen | PCR+ Seq | 65 | 40 | 62 |
| 24 | Zhao H (92) | 2015 | Chinese Academy of Medical Sciences | Beijing | 2010–2012 | FNA | PCR | 170 | 114 | 67 |
| 25 | Jin L (93) | 2016 | Wenzhou Medical University | Wenzhou | 2009–2014 | FFPE | Seq | 653 | 416 | 64 |
| 26 | Sun J (94) | 2016 | Peking Union Medical College Hospital (PUMCH) | Beijing | 2010–2013 | FFPE | Seq | 455 | 343 | 75 |
| 27 | Wen H (95) | 2016 | XinJiang Medical University | Urumqi | 2007–2011 | FFPE | Seq | 26 | 19 | 73 |
| 28 | Zhang B (96) | 2016 | Affiliated Hospital of the Academy of Military Medical Sciences | Beijing | 2011–2014 | FFPE | ARMS qPCR | 120 | 106 | 88 |
| 29 | Zheng L (97) | 2016 | First Affiliated Hospital of Anhui Medical University | Hefei | 2009–2012 | FFPE | PCR + Seq | 60 | 40 | 67 |
| 30 | Geng J (19) | 2017 | Beijing Children’s Hospital | Beijing | 1994–2014 | FFPE | qPCR | 48 | 17 | 35 |
| 31 | Li Q (98) | 2017 | Affiliated Cancer Hospital of Zhengzhou University | Zhengzhou | n/s | Fresh frozen | PCR + Seq | 34 | 18 | 53 |
| 32 | Zhang Q (99) | 2017 | Shanghai Tenth People’s Hospital of Tongji University School | Shanghai | 2015–2016 | FFPE | PCR | 438 | 379 | 87 |
| 33 | Guan Q (100) | 2018 | Fudan University Shanghai Cancer Center | Shanghai | 2012–2013 | FFPE | qPCR + Seq | 99 | 63 | 64 |
| 34 | Huang L (101) | 2018 | Wuhan Puai Hospital | Wuhan | 2010–2016 | FFPE | qPCR | 184 | 140 | 76 |
| 35 | Liang J (102) | 2018 | Beijing Cancer Hospital | Beijing | n/s | FFPE | DNA, RNA Seq | 355 | 257 | 72 |
| 36 | Liu Z (103) | 2018 | Shanghai Jiaotong University School of Medicine | Shanghai | 2016 | Fresh frozen | PCR + Seq | 145 | 81 | 56 |
| 37 | Ren H (104) | 2018 | Chongqing Medical University | Chongqing | 2016–2017 | Fresh frozen | Seq | 342 | 270 | 79 |
| 38 | Zheng B (105) | 2018 | Guangzhou Kingmed Diagnostics | Guangzhou | 2014–2016 | FNA | PCR | 55 | 37 | 67 |
| 39 | Zhou D (106) | 2018 | Inner Mongolia Peoples’ Hospital | Hohhot | 2016–2017 | FFPE | PCR | 50 | 37 | 74 |
| 40 | Chen B (107) | 2019 | Hospital of Jiangsu University | Jiangsu | 2014–2017 | FFPE | Seq | 116 | 70 | 60 |
| 41 | Gao J (108) | 2020 | The First Affiliated Hospital of USTC | Hefei | 2017–2018 | FFPE | ARMS qPCR | 60 | 39 | 65 |
| 42 | Huang M (109) | 2019 | Xijing Hospital | Xian | 2018–2019 | FFPE | Seq | 483 | 419 | 87 |
| 43 | Ji W (110) | 2019 | Beijing Shijitan Hospital | Beijing | 2012–2015 | FFPE | ARMS qPCR | 89 | 67 | 75 |
| 44 | Li X (111) | 2019 | Renji Hospital, Shanghai Jiaotong University | Shanghai | 2016–2018 | FNA | ARMS PCR | 777 | 674 | 87 |
| 45 | Li XJ (112) | 2019 | Jiangsu Province Hospital | Nanjing | 2016–2018 | FNA | qPCR | 333 | 304 | 91 |
| 46 | Lin ZM (113) | 2019 | Second Affiliated Hospital, Zhejiang University School of Medicine | Zhejiang | 2016–2018 | FNA | PCR | 1199 | 791 | 66 |
| 47 | Liu Y (114) | 2019 | Chongqing Medical University | Chongqing | 2016–2018 | FNA | PCR | 207 | 155 | 75 |
| 48 | Shen G (115) | 2019 | West China Hospital of Sichuan University | Chengdu | 2012–2015 | FFPE | PCR | 236 | 147 | 62 |
| 49 | Wang J (116) | 2019 | Beijing Hospital | Beijing | 2015–2018 | FFPE | qPCR | 444 | 384 | 86 |
| 50 | Yan C (117) | 2019 | Xijing Hospital | Shaanxi | 2015–2018 | FFPE | PCR | 2048 | 1715 | 84 |
| 51 | Yang T (118) | 2019 | West China Hospital, Sichuan University | Chengdu | n/s | FFPE | Seq | 326 | 269 | 83 |
| 52 | Zhou C (119) | 2019 | Liaocheng People's Hospital | Liaocheng | 2015–2016 | FFPE | qPCR | 162 | 135 | 83 |
ARMS-PCR, amplification refractory mutation system-polymerase chain reaction; FFPE, formalin fixed paraffin embedded tissues; FNA, fine needle aspiration; IHC, immunohistochemistry; n/s, not specified; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; Pyroseq, pyrosequencing; qPCR, quantitative polymerase chain reaction; Seq, sequencing.