Table 4. Diagnostic performance of BRAFV600E mutation, ACR TI-RADS, and combination.
| Diagnostic modality | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | AC (95% CI) |
|---|---|---|---|---|---|
| BRAFV600E | 81.8 (79.4–84.2) | 95.0 (89.5–99.6) | 99.6 (99.2–100.0) | 24.6 (19.1–30.2) | 75.3 (72.8–77.8) |
| TI-RADS 5 | 97.1 (96.0–98.1) | 68.9 (56.6–81.2) | 98.1 (97.2–98.9) | 58.8 (46.8–70.8) | 95.5 (94.3–96.8) |
| Combination | 97.7 (96.8–98.6) | 94.8 (88.9–99.7) | 99.6 (99.3–100.0) | 71.4 (61.1–81.7) | 97.5 (96.6–98.5) |
The numbers in parentheses are percentages. TI-RADS 5 was taken as the diagnostic threshold. Combination = BRAFV600E + TI-RADS 5. ACR TI-RADS, American College of Radiology Thyroid Imaging Reporting and Data System; PPV, positive predictive value; NPV, negative predictive value; AC, accuracy.