Table 2. Frequency of RAS mutations and PAX8/PPARγ rearrangement in FTC patients by country.
| Country/region | No. studies | NRAS | HRAS | KRAS | Any RAS | PAX8/PPARγ |
|---|---|---|---|---|---|---|
| No. with a mutation/total no. [%] | ||||||
| Asia | ||||||
| China | 1 (34) | 10/53 [19] | 4/53 [8] | 3/53 [3] | 17/53 [32] | 1/53 [2] |
| Japan | 10 (6,10,16,17,21-26) | 63/215 [29] | 5/158 [3] | 5/173 [3] | 73/215 [34] | 1/66 [2] |
| Korea | 8 (5,27-33) | 56/246 [23] | 21/223 [9] | 16/223 [7] | 93/246 [38] | 5/106 [5] |
| Malaysia | 1 (35) | 2/18 [11] | ||||
| Taiwan | 1 (36) | 1/8 [13] | 1/8 [13] | 1/8 [13] | 3/8 [38] | |
| Vietnam | 1 (10) | 4/23 [17] | 0/23 [0] | 0/23 [0] | 4/23 [17] | |
| India | 1 (37) | 0/8 [0] | 0/8 [0] | 0/8 [0] | 0/8 [0] | |
| Overall | 23 | 134/553 [24] | 31/473 [7] | 25/488 [5] | 190/553 [34] | 9/243 [4] |
| Europe | ||||||
| France | 4 (39-42) | 9/27 [33] | 0/11 [0] | 0/6 [0] | 9/32 [28] | 13/44 [30] |
| Germany | 3 (43-45) | 1/12 [8] | 0/12 [0] | 0/12 [0] | 1/12 [8] | 2/40 [5] |
| Italy | 7 (46-52) | 34/146 [23] | 8/120 [5] | 5/141 [4] | 47/146 [32] | 2/49 [4] |
| Portugal | 2 (53,54) | 2/25 [8] | 1/25 [4] | 0/25 [0] | 3/25 [12] | 13/41 [31] |
| Poland | 2 (55,56) | 2/55 [4] | 6/55 [11] | 2/55 [4] | 10/55 [18] | 0/20 [0] |
| UK | 2 (57,58) | 5/19 [26] | 3/19 [16] | 0/19 [0] | 8/19 [42] | |
| Switzerland | 1 (15) | 5/31 [16] | ||||
| Spain | 1 (59) | 2/10 [20] | 0/10 [0] | 0/10 [0] | 2/10 [20] | |
| Turkey | 2 (60,61) | 0/13 [0] | 0/13 [0] | 3/9 [33] | ||
| Croatia | 1 (62) | 7/18 [39] | ||||
| Denmark | 2 (63,64) | 3/24 [13] | 1/24 [4] | 0/24 [0] | 4/24 [17] | 7/44 [16] |
| Hungary | 1 (11) | 1/6 [17] | 2/6 [33] | 0/6 [0] | 3/6 [50] | |
| Norway | 1 (65) | 2/7 [29] | 1/7 [14] | 3/7 [43] | 0/7 [0] | |
| Sweden | 1 (66) | 10/34 [29] | ||||
| Overall | 30 | 61/331 [18] | 22/289 [8] | 7/311 [2] | 90/349 [26] | 62/337 [18] |
| North America | ||||||
| USA | 15 (67-81) | 26/76 [34] | 4/76 [5] | 2/86 [2] | 57/194 [29] | 48/149 [32] |
| Canada | 1 (11) | 0/10 [0] | 1/10 [10] | 0/10 [0] | 1/10 [10] | |
| Overall | 16 | 26/86 [30] | 5/86 [6] | 2/96 [2] | 58/204 [28] | 48/149 [32] |
| South America | ||||||
| Brazil | 1 (82) | 4/13 [31] | ||||
| Overall | 1 | 4/13 [31] | ||||
| Oceania | ||||||
| Australia | 2 (83,84) | 5/27 [19] | 3/27 [11] | 0/27 [0] | 8/27 [30] | 7/22 [32] |
| Overall | 2 | 5/27 [19] | 3/27 [11] | 0/27 [0] | 8/27 [30] | 7/22 [32] |
| Middle East | ||||||
| Saudi Arabia | 1 (38) | 1/10 [10] | 1/10 [10] | 0/10 [0] | 2/10 [20] | |
| Overall | 1 | 1/10 [10] | 1/10 [10] | 0/10 [0] | 2/10 [20] | |
FTC, follicular thyroid carcinoma.