Table 7. ThyroSeq v3: common genomic alterations and probability of cancer or NIFTP (27).
Genomic Alterations | Probability of cancer or NIFTP |
---|---|
PTEN | ~5–10% |
RAS alone | 40–80% |
Gene expression alteration | 50–80% |
THADA/IGF2 BP3 alone | 50–80% |
Copy number alterations | 60–70% |
RAS and other mutation(s) except TERT | 70–80% |
PAX8/PPARG alone | 50–90% |
TERT with or without other mutations | 80–95% |
RET/PTC alone | 95% |
BRAF V600E alone | 99% |
Others | 30–95% |