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. 2020 Nov 2;8:591132. doi: 10.3389/fped.2020.591132

Table 4.

Image findings, treatments, and outcomes of children with COVID-19 analyzed by meta-analysis.

Variable Number of studies Mean/prevalence 95% CI N Heterogeneity tests
Q I2 t2 p
Image findings (%)
Normal 45 26 18–35 413 588.99 92.53 0.29 <0.001
Unilateral pneumonia 28 30 25–35 237 45.04 40.05 0.02 0.02
Bilateral pneumonia 25 40 31–50 234 116.13 79.33 0.15 <0.001
Ground-glass opacity 38 33 26–40 318 157.54 76.51 0.13 <0.001
Pulmonary consolidation 13 10 5–16 29 19.66 38.95 0.03 0.07
Ground-glass opacities and consolidation 5 44 20–69 44 21.70 81.56 0.25 <0.001
Pleural effusion 6 1 0–6 7 8.26 39.50 0.02 0.14
Subpleural lesions 7 35 5–72 46 159.39 96.24 0.80 <0.001
White lung 4 2 0–6 5 3.46 13.24 0.01 0.33
Treatment (%)
Oxygen therapy 11 22 10–38 45 61.58 83.76 0.21 <0.001
Mechanical ventilation 6 9 1–23 26 36.92 86.46 0.17 <0.001
Interferon-alpha 18 81 64–95 254 187.34 90.93 0.53 <0.001
Ribavirin 12 57 26–86 158 216.91 94.93 0.94 <0.001
Oseltamivir 5 33 7–67 33 42.38 90.56 0.46 <0.001
Lopinavir/ritonavir 9 54 31–76 82 70.50 88.65 0.40 <0.001
Glucocorticoids 11 13 5–24 30 44.36 77.45 0.13 <0.001
Antibiotics 17 37 21–53 197 166.50 90.39 0.36 <0.001
Immunoglobulin 8 15 3–32 21 44.13 84.14 0.19 <0.001
Traditional Chinese medicine 6 31 14–50 36 17.15 70.84 0.12 <0.001
ICU (%) 7 7 1–14 34 26.97 77.75 0.06 <0.001
Outcomes (%)
Discharged 33 79 68–88 649 290.79 89.00 0.32 <0.001
Death 3 1 0–2 6 4.68 57.27 0.01 0.1

Q, Cochran's Q statistic for heterogeneity; I2, I2 Index for the degree of heterogeneity; t2, tau-squared measure of heterogeneity.