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The role of insulin and AMPK in growth, differentiation, and survival of cells. AMPK, 5′-AMP–activated protein kinase; IRK, insulin receptor kinase; PI3K, phosphatidylinositol 3-kinase; CAP–CBL–TC10, the Cb1-associated protein (CAP)–casitas B-lineage lymphoma (CBL)–ras-like protein TC10; PKC, protein kinase C; JNK-1, c-Jun N-terminal kinase 1; SIK2, salt-inducible kinase 2.
