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. 2020 Nov 2;8:584198. doi: 10.3389/fbioe.2020.584198

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Copyright © 2020 Ait Oumghar, Barkaoui and Chabrand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the biochemical interactions and feedback loops within a bone remodeling process in the presence of prostate cancer (PC) cells that were adopted in the mathematical model. OBu, uncommitted osteoblasts; OBp, preosteoblasts; OBa, active osteoblasts; OCp, preosteoclasts; OCa; active osteoclasts; OCap, apoptotic osteoclasts; PCe, early PC cells; PCI, late PC cells; BONEt, total bone; BONEp, bone production; and BONEr, bone resorption.