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. 2020 Nov 2;8:584198. doi: 10.3389/fbioe.2020.584198

FIGURE 3.

FIGURE 3

Schematic illustration of the biochemical interactions during the bone remodeling process after the adhesion of myeloma cells into the bone microenvironment. Interleukin-6 (IL-6) expression and multiple myeloma–bone marrow stromal cell (MM–BMSC) adhesion are the central factors controlling the process.