TABLE 2.

Complications and clinical manifestation of Paget’s disease of bone (Ralston, 2013).

Musculoskeletal	Bone pain - bowing of long bones - enlarged skull – osteoarthritis of joints adjacent to pagetic lesions – bone fractures – sarcoma
	– giant cell tumors
Neurological	Hearing loss – platybasia – spinal stenosis – vascular steal syndromes – cranial nerve deficits (rare)
Cardiovascular	High output heart failure – aortic stenosis – endocardial calcifications
Genitourinary	Nephrolithiasis
Metabolic	Hypercalcemia (in some patients) – immobilization hypercalciuria – hyperuricemia