Table 1.
Upregulated genes involved in endocytosis and cell-cycle pathways in Ast-treated DM Rats compared to DM rats
| Pathway | Gene | Description | Log2FC |
|---|---|---|---|
| Ast vs DM | |||
| Endocytosis | CBL | Cbl proto-oncogene | 1.91 |
| RT1-M2 | RT1 class Ib, locus M2 | 1.81 | |
| ARRB1 | Arrestin β1 | 1.71 | |
| GRK3 | G protein–coupled receptor kinase 3 | 1.59 | |
| DAB2 | DAB2 clathrin adaptor protein | 1.44 | |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat, and PH domain 2 | 1.43 | |
| MVB12B | Multivesicular body subunit 12B | 1.34 | |
| CSF1R | Colony stimulating factor 1 receptor | 1.21 | |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat, and PH domain 1 | 1.18 | |
| Cell cycle | ESPL1 | Extra spindle pole bodies like 1 separase | 3.91 |
| TTK | Ttk protein kinase | 3.30 | |
| CDK6 | Cyclin-dependent kinase 6 | 2.25 | |
| MCM5 | Minichromosome maintenance complex component 5 | 2.09 | |
| MCM6 | Minichromosome maintenance complex component 6 | 2.07 | |
| MCM3 | Minichromosome maintenance complex component 3 | 1.97 | |
| PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | 1.15 |