Table 1.
Phenotypes of E10.5 embryos from intercrosses of Pdgfrafl/fl;Pdgfrbfl/fl mice with Pdgfra+/fl;Pdgfrb+/fl;Wnt1-Cre+/Tg mice.
| Genotype | Expected | Observed | Normal | Dead | Abnormal head | Facial bleb | Facial hemorrhage | Body wall closure defects |
|---|---|---|---|---|---|---|---|---|
| α+/fl;β+/fl;W1C+/+ | 0.125 | 0.092 | 10/10 | 1 | 0/10 | 0/10 | 0/10 | 0/10 |
| α+/fl;β+/fl;W1C+/Tg | 0.125 | 0.192 | 19/21 | 2 | 0/21 | 2/21 | 0/21 | 0/21 |
| α+/fl;βfl/fl;W1C+/+ | 0.125 | 0.117 | 13/14 | 0 | 1/14 | 0/14 | 0/14 | 0/14 |
| α+/fl;βfl/fl;W1C+/Tg | 0.125 | 0.075 | 7/9 | 0 | 1/9 | 0/9 | 1/9 | 0/9 |
| αfl/fl;β+/fl;W1C+/+ | 0.125 | 0.142 | 14/14 | 3 | 0/14 | 0/14 | 0/14 | 0/14 |
| αfl/fl;β+/fl;W1C+/Tg | 0.125 | 0.117 | 8/11 | 3 | 1/11 | 1/11 | 1/11 | 2/11 |
| αfl/fl;βfl/fl;W1C+/+ | 0.125 | 0.117 | 12/14 | 0 | 1/14 | 0/14 | 1/14 | 0/14 |
| αfl/fl;βfl/fl;W1C+/Tg | 0.125 | 0.150 | 13/16 | 2 | 1/16 | 1/16 | 1/16 | 0/16 |