Table 5.
Deterministic sensitivity analysis results.
| Parameter | Mean Value (SD) | ICER |
|---|---|---|
| Base Case | ||
| LF-iMR device costa,b | 1,000,000 (200,000) | n.a. |
| Cost (€ 2018) (iMR) | 11,599 | |
| Cost (€ 2018) (Conv. OR) | 10,810 | |
| Postoperative KPS (iMR)b | 84 (9) | 111 |
| Postoperative KPS (Conv. OR)b | 77.1 (18) | |
| R-KPS b | 52 (10.4) | 46 |
| R-KPS (Conv. OR)b | 35 (7) | |
| 1-year PFS (iMR)b | 333 (76) | 21 |
| 1-year PFS (Conv. OR)b | 295 (40) | |
| New Value on the Sensitivity Analysis | ||
| Scenario A (conservative)c | ||
| Postoperative KPS (iMR) | 75 | Dominated |
| R-KPS | 41.6 | 118 |
| 1-year PFS | 255 | Dominated |
| Scenario B (favorable)d | ||
| Postoperative (iMR) | 93 | 50 |
| R-KPS | 62.4 | 29 |
| 1-year PFS | 410 | 7 |
| Scenario C (favorable)e | ||
| LF-iMR device cost | 800,000e
408f |
n.a. |
| Postoperative KPS (iMR) | 84 | 88 |
| R-KPS | 52 | 36 |
| Scenario D (HGG sub-group)g | ||
| Cost (€ 2018) (iMR) | 11,608 | n.a. |
| Cost (€ 2018) (Conv. OR) | 10,853 | |
| Postoperative KPS (iMR) | 84.1 | 88 |
| Postoperative KPS (Conv. OR) | 75.5 | |
| R-KPS (iMR) | 55 | 44 |
| R-KPS (Conv. OR) | 31 | |
| 1-year PFS (iMR) | 322 | 20 |
| 1-year PFS (Conv. OR) | 284 | |
ICER, Incremental cost-effectiveness ratio: cost per additional unit of effectiveness (per additional point of postoperative KPS or percentage point of R-KPS); KPS, Karnofsky performance status; R-KPS, Resection and postoperative KPS; SD, Standard deviation.
aTotal cost of the iMR device.
bSD is based on the variation of 20% as recommended in the international guidelines in health economic evaluation (18).
cScenario A: Worst possible clinical outcomes of the iMR.
dScenario B: Best possible clinical outcomes of the iMR.
eScenario C: Reduction of the cost of the iMR device due to its extensive use.
fCost per intervention.
g Scenario D: Only considering the HGG cohort.