. 2020 Nov 2;10:519073. doi: 10.3389/fonc.2020.519073

Table 1.

Characteristics of the included studies.

First author	Publish year	Region	Study type	Number of patients			EGFR mutation			Female (%)	Age(years)	Smoker(%)	Adenocarcinoma (%)	Stage	Lymph node metastasis (%)	Brain metastasis (%)	EGFR mutation detection methods	Scores Of AHRQ
First author	Publish year	Region	Study type	Xuanwei	Non-Xuanwei	Total	Yes	No	Rate	Female (%)	Age(years)	Smoker(%)	Adenocarcinoma (%)	Stage	Lymph node metastasis (%)	Brain metastasis (%)	EGFR mutation detection methods	Scores Of AHRQ
Guo et al. (27)	2019	China, Xuanwei	Retro	85	NA	85	39	46	45.88%	41.18%	54 (36-78)	NG	80.00%	NG	NG	NG	Targeted NGS	10
Zhou et al. (28)	2018	China, Yunnan	Retro	20	192	212	64	148	30.19%	38.21%	57.1 (31-86)	44.81%	81.60%	I, II, III, IV	NG	18.87%	Super ARMS-PCR and dd PCR	11
Zhou et al. (21)	2017	China, Yunnan	Retro	63	384	447	156	291	34.90%	44.97%	<65 (69.4%); 65-75 (23.5%); >75 (7.2%)	47.43%	86.58%	I, II, III, IV	NG	14.32%	ARMS-PCR	11
Chen et al. (13)	2016	China, Yunnan	Retro	90	168	258	124	134	48.06%	52.33%	<=60 (68.6%); >60 (31.4%)	27.13%	87.60%	I, II, III, IV	29.07%	NG	ARMS-PCR	10
Yang et al. (22)	2016	China, Yunnan	Retro	81	169	250	131	119	52.40%	NG	NG	NG	NG	NG	NG	NG	ARMS-Taqman	10
Yang et al. (26)	2016	China, Xuanwei	Retro	63	NA	63	35	28	55.56%	42.86%	<50 (54.0%); >=50 (46.0%)	39.68%	84.13%	NG	17.46%	NG	ARMS-Taqman	10
Hosgood et al. (14)	2013	China, Xuanwei	Retro	40	NA	40	14	26	35.00%	NG	46.5 ± 10	0	80.00%	NG	NG	NG	SNaPshot and separate PCR-based sizing technique	10

Retro, Retrospective study; EGFR, Epidermal growth factor receptor; NA, Not Available; NG, Not given; AHRQ, Agency for Healthcare Research and Quality; NGS, Next generation sequencing; ARMS, super amplification refractory mutation system; PCR, polymerase chain reaction; dd PCR, Droplet Digital polymerase chain reaction; GS, gene sequencing.