Table 2.
Comparison of the incidence of EGFR mutation of NSCLC patients between Xuanwei and non-Xuanwei regions.
| Xuanwei | Non-Xuanwei | META | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | Total | Rate | Yes | No | Total | Rate | OR | 95%CI | P-value | |||
| Common mutation | Zhou et al. (28) | 2018 | 3 | 5 | 8 | 37.50% | 28 | 28 | 56 | 50.00% | 0.600 | (0.131-2.755) | |
| Zhou et al. (21) | 2017 | 8 | 19 | 27 | 29.63% | 101 | 28 | 129 | 78.29% | 0.117 | (0.046-0.295) | ||
| Chen et al. (13) | 2016 | 14 | 37 | 51 | 27.45% | 63 | 10 | 73 | 86.30% | 0.060 | (0.024-0.149) | ||
| Yang et al. (22) | 2016 | 21 | 22 | 43 | 48.84% | 66 | 22 | 88 | 75.00% | 0.318 | (0.148-0.686) | ||
| Overall | 46 | 83 | 129 | 258 | 88 | 346 | 0.176 | (0.069-0.448) | <0.001 | ||||
| (Heterogeneity: I2 =72.4%, p=0.0012) | |||||||||||||
| Uncommon mutation | Zhou et al. (28) | 2018 | 5 | 3 | 8 | 62.50% | 28 | 28 | 56 | 50.00% | 1.667 | (0.363-7.652) | |
| Zhou et al. (21) | 2017 | 19 | 8 | 27 | 70.37% | 28 | 101 | 129 | 21.71% | 8.567 | (3.393-21.628) | ||
| Chen et al. (13) | 2016 | 37 | 14 | 51 | 72.55% | 10 | 63 | 73 | 13.70% | 16.650 | (6.720-41.256) | ||
| Yang et al. (22) | 2016 | 22 | 21 | 43 | 51.16% | 22 | 66 | 88 | 25.00% | 3.143 | (1.458-6.777) | ||
| Overall | 83 | 46 | 129 | 88 | 258 | 346 | 5.685 | (2.231-14.486) | <0.001 | ||||
| (Heterogeneity: I2 =72.4%, p=0.0012) | |||||||||||||
OR, odds ratio; CI, confidence interval.