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. 2020 Nov 2;12:576025. doi: 10.3389/fnagi.2020.576025

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Copyright © 2020 Franchetti, Bharadwaj, Nguyen, Van Etten, Klimentidis, Hishaw, Trouard, Raichlen and Alexander.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic outline of the image processing steps involved in extracting regional lobar WMH volumes. The process combines outputs from the multispectral LST processing of a participant’s T1-weighted and T2-FLAIR scans (blue text boxes), with those from the FreeSurfer (https://surfer.nmr.mgh.harvard/fswiki) processing of the MNI152 template (gray text boxes), to provide WMH volumes shown for frontal (red), temporal (cyan), parietal (yellow), and occipital (magenta) lobar regions (green text box). LST, Lesion Segmentation Toolbox (Schmidt et al., 2012); WMH, White Matter Hyperintensities; MNI152, The Montreal Neurological Institute template (McConnell Brain Imaging Centre, McGill University) derived from the linear and high-dimensional non-linear registration of 152 T1-weighted structural images into a common average space; GM, Gray Matter; WM, White Matter; ANTs, Advanced Normalization Tools (Avants et al., 2011); White arrow with A and P, anterior and posterior directional orientation of MRI axial brain slices.