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. 2020 Nov 2;10:578985. doi: 10.3389/fonc.2020.578985

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Copyright © 2020 Tang, Xiao, Shen, Zhuang, Xie, Zhang, Yang, Guan, Shen, Chen, Lai, Chen, Chen, Dai, Wang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ioversol exhibits a strong CEST signal. (A) CEST map of five different pH phantoms with a flip angle of 350°. (B) Z-spectra of 50 mM ioversol at different pH values (6.0, 6.4, 6.8, 7.2, 7.6) with a flip angle of 350°. (C) MTR_asym curves of 5 different pH ioversol phantoms measured with a flip angle of 350°. (D) ST% based on of different pH phantoms with different flip angles. CEST, chemical exchange saturation transfer; MTR_asym, asymmetric magnetization transfer ratio; ST%, saturation transfer effect.