Table 5.
Pro-apoptosis related biological processes from GO analysis.
| Downregulated/upregulated miRNAs | GO ID | Term | Count | p | Genes |
|---|---|---|---|---|---|
| Downregulated miRNAs | 0043065 | Positive regulation of apoptotic process | 28 | <0.01 | ING5, ERBB4, WT1, TGFB2, PYCARD, IL1B, TRP53INP1, UNC5C, PHLDA1, NET1, KCNMA1, EEF1A2, STK4, ATF6, TRIM35, TNFSF10, ITGA6, RPS6KA2, RIPK1, GSK3B, CASP12, SMPD1, LRP6, MAPK8, TRP73, ABL1, BIN1, and SLC9A1 |
| 0043525 | Positive regulation of neuron apoptotic process | 10 | <0.01 | KCNMA1, NCF2, GRIK2, GSK3B, IL1B, TFAP2A, MAPK8, ABL1, TGFB2, and ATF2 | |
| 2001235 | Positive regulation of apoptotic signaling pathway | 7 | <0.01 | ING5, TRP63, TRP53INP1, MAPK8, CAMK2B, CTSC, and TRP73 | |
| Upregulated miRNA | 2001237 | Negative regulation of extrinsic apoptotic signaling pathway | 5 | <0.01 | SH3RF1, ITGA6, RB1CC1, TCF7L2, and ACVR1 |
| 0043524 | Negative regulation of neuron apoptotic process | 8 | <0.05 | HIF1A, SET, KDM2B, FYN, GABRB2, MECP2, PPT1, and SIX4 |