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. 2020 Nov 2;10:596318. doi: 10.3389/fonc.2020.596318

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Copyright © 2020 Zhang, Liu, Wu, Chen and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulation of the development trajectory of B cells and the analysis of gene expression pattern. Simulation of the differentiation trajectory of B cells group from three sources, healthy donors (HD), patients with liver cirrhosis (LC), and patients with hepatocellular carcinoma (HCC), (A) pseudo-trajectory of B cells, (B) cell type transition, (C) cell source transition. (D) Heatmap shows the gene expression dynamics of B cell group. Genes (rows) are clustered and cells (columns) are ordered according to the pseudotime development. Genes are listed in Table S2 . Gene clusters III, V, and II were selected for further analysis. (E) The GO function enrichment analysis results of gene cluster III, V and II of B cell group, p.adjust < 0.01. (The first 12 GO terms are retained). (F) Expression patterns of some genes enriched in humoral immunity under three sources.