Table 2.

Description of parameters used in the simulation study based on human cancer parameters. The numbers in each cell indicate the minimum and maximum (range) of their corresponding variables used in the simulations.

Name	Examples	Tumor $K_1$ (${\min }^{-1}$)	Tumor $k_2$ (${\min }^{-1}$)	Normal $K_1$ (${\min }^{-1}$)	Normal $k_2$ (${\min }^{-1}$)	$BP$
Peptides	Linear, Cyclin	[0.18, 0.63]	[0.29, 1.03]	[0.16, 0.43]	[0.26, 0.7]	[13.5, 67.5]
Low MW antibody-fragments	Centyrin, Affibody, Knottin	[0.0198, 0.0952]	[0.032, 0.156]	[0.0196, 0.0906]	[0.032, 0.148]	[13.12, 15]
High MW antibody-fragments	Fab, Diabody, scFv	[0.002, 0.01]	[3.28e-3, 0.0164]	[0.002, 0.01]	[0.003, 0.016]	[0.187, 3.75]
Antibodies	IgG, Minibody	[2.1E-04, 5.6E-03]	[2.4E-04, 9.1E-03]	[3.1E-04, 5.6E-03]	[5.1E-04, 9.2E-03]	[0.0185, 0.037]