Table III.
Primary outcome and secondary outcome of 3 cohorts
| Parameter | NHFOV | NIPPV | P1 | NHFOV | NCPAP | P2 | NIPPV | NCPAP | P3 |
|---|---|---|---|---|---|---|---|---|---|
| IMV: | 0.016 | 0.027 | 1.00 | ||||||
| Yes | 13 (10.3) | 27 (21.4) | 9 (9.4) | 20 (20.8) | 25 (18.9) | 25 (18.7) | |||
| No | 113 (89.7) | 99 (78.6) | 87 (90.6) | 76 (79.2) | 109 (81.1) | 109 (81.3) | |||
| NEC: | 0.076 | 0.733 | 0.473 | ||||||
| Yes | 9 (7.1) | 3 (2.4) | 4 (4.2) | 5 (5.2) | 3 (2.2) | 5 (3.7) | |||
| No | 117 (92.9) | 123 (97.6) | 92 (95.8) | 91 (94.8) | 131 (97.8) | 129 (96.3) | |||
| ROP: | 0.424 | 0.551 | 0.475 | ||||||
| Yes | 6 (4.8) | 9 (7.1) | 5 (5.2) | 7 (7.3) | 8 (6.0) | 11 (8.2) | |||
| No | 120 (95.2) | 117 (92.9) | 91 (94.8) | 89 (92.7) | 126 (94.0) | 123 (91.8) | |||
| PNX: | 0.134 | 1.00 | 1.00 | ||||||
| Yes | 3 (2.4) | 0 (0.0) | 1 (1.0) | 1 (1.0) | 0 | 0 | |||
| No | 123 (97.6) | 126 (100) | 95 (99.0) | 95 (99.0) | 134 | 134 | |||
| BPD: | 0.183 | 0.488 | 0.112 | ||||||
| Yes | 10 (7.9) | 5 (4.0) | 9 (9.4) | 12 (12.5) | 7 (5.2) | 14 (10.4) | |||
| No | 116 (92.1) | 121 (96) | 87 (90.6) | 84 (86.5) | 127 (94.8) | 120 (87.3) | |||
| Death: | 0.151 | 0.470 | 0.156 | ||||||
| Yes | 6 (4.8) | 2 (1.6) | 5 (5.2) | 3 (3.1) | 2 (1.5) | 0 (0) | |||
| No | 120 (95.2) | 124 (98.4) | 91 (94.8) | 93 (96.9) | 132 (98.5) | 134 (100) | |||
| HS | 31.29 ±16.34 | 27.73 ±14.79 | 0.339 | 30.69 ±16.92 | 33.46 ±21.37 | 0.140 | 24.80 ±14.61 | 33.22 ±20.2 | 0.002 |
IMV – invasive mechanical ventilation, NEC – necrotizing enterocolitis, ROP – retinopathy of prematurity, BPD – bronchopulmonary dysplasia, PNX – pneumothorax, HS – hospital stay. P1 – p-value of NHFOV vs. NIPPV, P2 – p-value of NHFOV vs. NCPAP, P3 – p-value of NIPPV vs. NCPAP.