Table 2.
GO analysis for programmed death 1/programmed death ligand 1/programmed death ligand 2 co-expression gene
|
ID
|
Description
|
Gene ratio
|
P
value
|
P
adjust
|
Gene ID
|
Count
|
| GO: 0042110 | T cell activation | 16/27 | 1.23 × 10-19 | 1.10 × 10-16 | PTPN6/CD3E/LCK/PDCD1/CD3G/IDO1/TNFRSF4/TIGIT/PTPRC/CD40LG/PRDM1/EOMES/CD2/CD5/CD8A/IRF4 | 16 |
| GO: 0050863 | Regulation of T cell activation | 12/27 | 4.55 × 10-15 | 2.05 × 10-12 | PTPN6/CD3E/LCK/PDCD1/IDO1/TIGIT/PTPRC/CD40LG/PRDM1/CD2/CD5/IRF4 | 12 |
| GO: 0051249 | Regulation of lymphocyte activation | 13/27 | 2.40 × 10-14 | 5.40 × 10-12 | PTPN6/CD3E/LCK/PDCD1/IDO1/TNFRSF4/TIGIT/PTPRC/CD40LG/PRDM1/CD2/CD5/IRF4 | 13 |
| GO: 1903037 | Regulation of leukocyte cell-cell adhesion | 10/27 | 5.69 × 10-12 | 1.02 × 10-9 | PTPN6/CD3E/LCK/PDCD1/IDO1/TIGIT/PTPRC/CD40LG/CD5/ITGA4 | 10 |
| GO: 0007159 | Leukocyte cell-cell adhesion | 10/27 | 1.68 × 10-11 | 2.53 × 10-9 | PTPN6/CD3E/LCK/PDCD1/IDO1/TIGIT/PTPRC/CD40LG/CD5/ITGA4 | 10 |
| GO: 0007204 | Positive regulation of cytosolic calcium ion concentration | 9/27 | 3.25 × 10-10 | 2.66 × 10-8 | PTPN6/LCK/CD19/PTPRC/CXCR3/FASLG/CXCR4/CD52/CXCL9 | 9 |
| GO: 0050852 | T cell receptor signaling pathway | 9/27 | 1.56 × 10-9 | 1.00 × 10-7 | PTPN6/CD3E/LCK/HLA-DQB1/CD3G/PTPRC/CD247 | 7 |
| GO: 0055074 | Calcium ion homeostasis | 9/27 | 1.08 × 10-8 | 4.87 × 10-7 | PTPN6/LCK/CD19/PTPRC/CXCR3/FASLG/CXCR4/CD52/CXCL9 | 9 |
| GO: 0051209 | Release of sequestered calcium ion into cytosol | 6/27 | 1.42 × 10-8 | 5.81 × 10-7 | PTPN6/LCK/CD19/PTPRC/FASLG/CXCL9 | 6 |
| GO: 0006968 | Cellular defense response | 5/27 | 2.52 × 10-8 | 8.11 × 10-7 | TNFRSF4/CD19/PRF1/CXCL9/SH2D1A | 5 |
| GO: 0050867 | Positive regulation of cell activation | 5/8 | 2.00 × 10-7 | 5.23 × 10-5 | PDCD1LG2/JAK2/CD274/ITPKB/PDGFRB | 5 |
| GO: 0022407 | Regulation of cell-cell adhesion | 5/8 | 2.11 × 10-7 | 5.23 × 10-5 | PDCD1LG2/JAK2/CD44/CD274/ITPKB | 5 |
| GO: 0045785 | Positive regulation of cell adhesion | 5/8 | 2.36 × 10-7 | 5.23 × 10-5 | PDCD1LG2/JAK2/CD44/CD274/ITPKB | 5 |
| GO: 0060333 | Interferon-gamma-mediated signaling pathway | 3/8 | 6.13 × 10-6 | 0.000528087 | JAK2/CD44/NCAM1 | 3 |
| GO: 0007159 | Leukocyte cell-cell adhesion | 4/8 | 6.35 × 10-6 | 0.000528087 | PDCD1LG2/CD44/CD274/ITPKB | 4 |
| GO: 2001269 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 2/8 | 7.36 × 10-6 | 0.000543547 | JAK2/FAS | 2 |
| GO: 0046007 | Negative regulation of activated T cell proliferation | 2/8 | 8.99 × 10-6 | 0.000597772 | PDCD1LG2/CD274 | 2 |
| GO: 0032693 | Negative regulation of interleukin-10 production | 2/8 | 2.22 × 10-5 | 0.001230174 | PDCD1LG2/CD274 | 2 |
| GO: 0032516 | Positive regulation of phosphoprotein phosphatase activity | 2/8 | 3.42 × 10-5 | 0.001626763 | JAK2/PDGFRB | 2 |
| GO: 0055093 | Response to hyperoxia | 2/8 | 3.42 × 10-5 | 0.001626763 | FAS/PDGFRB | 2 |
P < 0.05 was considered significant.