Table 3.
Comparison of RON (tumor cells) and PD-L1 (tumor-infiltrating mononuclear cells) expression and clinicopathological characteristics of patients with colorectal cancer in the FAHZUSM cohort, n (%)
| Characteristic | Cases |
RON and PD-L1 (TIMCs) expression in the tumor microenvironment
|
||||
|
RON low/PD-L1 low
|
RON high/PD-L1 low
|
RON low/PD-L1 high
|
RON high/PD-L1 high
|
P
value
|
||
| Number of cases | 338 | 177 | 70 | 65 | 26 | |
| Age (mean ± SD) | 61.24 ± 12.555 | 60.37 ± 12.299 | 62.40 ± 12.518 | 61.03 ± 13.286 | 64.58 ± 12.436 | 0.348 |
| Sex | ||||||
| Man | 197 (58.3) | 108 (61) | 35 (50.0) | 40 (61.5) | 14 (52.8) | 0.368 |
| Women | 141 (41.7) | 68 (39) | 35 (50.0) | 25 (38.5) | 12 (46.2) | |
| Principal diagnosis | ||||||
| Rectum | 200 (59.2) | 116 (65.5) | 37 (52.9) | 28 (43.1) | 19 (73.1) | 0.004 |
| Colon | 138 (40.8) | 61 (34.5) | 33 (47.1) | 37 (56.9) | 7 (26.9) | |
| Pathological grade | ||||||
| Well/moderate | 8 (2.4) | 3 (1.7) | 2 (2.9) | 3 (4.6) | 0 (0) | 0.492 |
| Poor | 306 (90.5) | 158 (89.3) | 66 (94.3) | 58 (89.2) | 24 (92.3) | |
| Unknown | 24 (7.1) | 16 (9.0) | 2 (2.9) | 4 (6.2) | 2 (7.7) | |
| T stage | ||||||
| Tis-T2 | 96 (28.4) | 64 (36.2) | 9 (12.9) | 16 (2.6) | 7 (26.9) | 0.002 |
| T3 | 155 (45.9) | 82 (46.3) | 36 (51.4) | 28 (43.1) | 9 (34.6) | |
| T4 | 87 (25.7) | 31 (17.5) | 25 (35.7) | 21 (32.3) | 10 (38.5) | |
| N stage | ||||||
| N0 | 226 (66.9) | 125 (70.6) | 39 (55.7) | 47 (72.3) | 15 (57.7) | 0.075 |
| N (1-2) | 112 (33.1) | 52 (29.4) | 31 (44.3) | 18 (27.7) | 11 (42.3) | |
| M stage | ||||||
| M0 | 326 (96.4) | 173 (97.7) | 68 (97.1) | 61 (93.8) | 24 (92.3) | 0.235 |
| M1 | 12 (3.6) | 4 (2.3) | 2 (2.9) | 4 (2.3) | 2 (7.7) | |
| Stage | ||||||
| 0-II | 221 (65.4) | 123 (69.5) | 39 (55.7) | 45 (69.2) | 14 (53.8) | 0.104 |
| III-IV | 117 (34.6) | 54 (30.5) | 31 (33.3) | 20 (30.8) | 12 (46.2) | |
| Histological type | ||||||
| Adenocarcinoma | 287 (84.9) | 152 (85.9) | 62 (88.6) | 60 (92.3) | 13 (50) | < 0.001 |
| Mucinous/SRCC | 40 (11.8) | 21 (11.9) | 7 (10.0) | 3 (4.6) | 9 (34.6) | |
| Other | 11 (3.3) | 4 (2.3) | 1 (1.4) | 2 (3.1) | 4 (15.4) | |
| Treatment | ||||||
| Yes | 298 (88.2) | 83 (46.9) | 22 (31.4) | 30 (46.2) | 24 (92.3) | < 0.001 |
| No | 32 (9.5) | 74 (41.8) | 38 (54.3) | 25 (38.5) | 1 (3.8) | |
| Unknown | 8 (2.4) | 20 (11.3) | 10 (14.3) | 10 (15.4) | 1 (3.8) | |
Bold entries indicate statistical significance (P < 0.05). RON: Recepteur d’origine nantais; PD-L1: Programmed death ligand 1; TCs: Tumor cells; TIMCs: Tumor-infiltrating mononuclear cells; FAHZUSM: The First Affiliated Hospital, Zhejiang University School of Medicine.