Table 3.
Residual kinase activity in the presence of compound 7 at 50 μM.a
| Protein kinase | Residual activity (%) | Protein kinase | Residual activity (%) | Protein kinase | Residual activity (%) |
|---|---|---|---|---|---|
| EphA4 | 27 | Clk2 | 67 | PKCα | 92 |
| GSK3β | 29 | Abl | 69 | MEK1 | 95 |
| CK1γ1 | 31 | Chk2 | 72 | JAK2 | 98 |
| ACVR1 (ALK2) | 34 | TBK1 | 75 | MKNK1 (MNK1) | 101 |
| Clk4 | 39 | CDK1/cyclinB | 78 | PDGFRα | 102 |
| MLCK (MLCK2) | 39 | Dyrk1A | 79 | DAPK3 | 104 |
| STK17A (DRAK1) | 48 | Clk1 | 80 | EGFR | 106 |
| CK2ά | 48 | HIPK3 | 82 | CDK2/cyclinE | 107 |
| GSG2 (Haspin) | 55 | Clk3 | 86 | ROCK1 | 107 |
| pim1 | 57 | RIPK2 | 86 | cKit | 116 |
| HIPK2 | 57 | MuSK | 90 |
a
Results were obtained with ATP concentration adjusted to the respective Km of each kinase. Duplicate values did not differ by more than 17% in all assays.