Fig. 2. Workflow of the target assessment process according to the GOT-IT recommendations.

Steps 1–7: the steps of the GOT-IT (Guidelines On Target Assessment for Innovative Therapeutics) workflow to define a project-specific critical path. The dotted arrow indicates an important data feedback mechanism, highlighting the recurrent nature of the data review exercise for each assessment block after a certain set of information has been collected. The design of studies and experiments as well as the definition of goals and expectations, specifying the direction of a translational project, can be facilitated by completing a target assessment project plan at the beginning of a project (see Supplementary Table 2 for a template).