Table 4.
Blood biochemistry of each treatment group in vivo on day 29 (n = 7)
| Control (PBS) | SeV/ΔF/GFP | SeV/ΔF/FIR | P-value* | P-value** | |
|---|---|---|---|---|---|
| T-Bil (mg/dL) | 0.067 ± 0.023 | 0.041 ± 0.020 | 0.076 ± 0.040 | 0.043 | 0.064 |
| AST (IU/L) | 141.7 ± 53.9 | 112.1 ± 46.2 | 181.0 ± 238.3 | 0.292 | 0.467 |
| ALT (IU/L) | 70.0 ± 43.9 | 71.3 ± 31.7 | 90.6 ± 131.1 | 0.951 | 0.712 |
| LDH (IU/L) | 2676.9 ± 1265.4 | 1712.1 ± 463.8 | 2286.4 ± 1319.1 | 0.083 | 0.299 |
| BUN (mg/dL) | 22.40 ± 3.49 | 21.94 ± 2.30 | 21.70 ± 3.32 | 0.778 | 0.876 |
| Cr (mg/dL) | 0.170 ± 0.019 | 0.123 ± 0.026 | 0.167 ± 0.062 | 0.002 | 0.11 |
Each value represents the median ± SD.
*
SeV/ΔF/GFP (1 × 108 CIU/body) compared with the control.
**
SeV/ΔF/FIR (1 × 108 CIU/body) compared with SeV/ΔF/GFP. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine; LDH, lactate dehydrogenase; CIU, cell-infectious units; SeV/ΔF/FIR, fusion gene deleted non-transmissible Sendai virus vector encoding FUSE-binding protein-interacting repressor; SeV/ΔF/GFP, fusion gene deleted non-transmissible Sendai virus vector encoding green fluorescent protein; T-Bil, total bilirubin.