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. 2020 Nov 10;9:255–272. doi: 10.2147/ITT.S229667

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© 2020 Singh et al.

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JAK-STAT signaling pathways. JAK inhibitors stop the downstream functions of inflammatory cytokines in AD. Inhibition of JAKs blocks their transphosphorylation, further inhibiting the phosphorylation and dimerization of STATs. This ultimately inhibits the dimerized STATs from acting as transcription factors for the inflammatory cytokines and blunts the overall inflammatory response.

Abbreviations: DNA, deoxyribonucleic acid; EPO, erythropoietin; IFN, interferon; IL, interleukin; JAK, Janus kinase; P, phosphate; STAT, signal transducer and activator of transcription; SYK, spleen tyrosine kinase; TYK2, non-receptor tyrosine-protein kinase.