Table 3.
Parameters of flux, time lag and permeability constant for each formulation with the corresponding length of microneedles (0.25 mm, 2.25 mm and without using microneedles) used for the in-vitro percutaneous penetration studies
|
Formulation
|
Flux
|
Permeability constant X 10 -2 (cm/h) | Time lag (h) |
|---|---|---|---|
| (µg/cm2*h) | |||
| TP W (2.25) | 105.2 | 1.59 | 20.1644 |
| TP W (0.25) | 103.3 | 1.58 | 20.7609 |
| TP W | 38.5 | 0.59 | 18.9740 |
| TP 1% (2.25) | 115.2 | 1.75 | 16.7378 |
| TP 1% (0.25) | 111.4 | 1.70 | 19.1194 |
| TP 1% | 90.0 | 1.37 | 19.4833 |
| TP 3% (2.25) | 70.5 | 1.07 | 20.4454 |
| TP 3% (0.25) | 67.1 | 1.02 | 21.7973 |
| TP 3% | 40.9 | 0.62 | 20.4572 |