Table 1.
Inhibition %, IC50 values and Equivalents of the Compounds (1-11) against AChE, BChE, Urease and Tyrosinasea.
Inhibition (%)
b
|
IC
50
(µg/mL)
|
Equivalent (µg kojic acid or
thiourea activity/ mg compound) |
|||||||
---|---|---|---|---|---|---|---|---|---|
No | Compounds | AChE | BchE | Urease | Tyrosinase | AChE | BChE | Urease | Tyrosinase |
1 | Rosmarinic Acid | 20.18±0.21 | 42.76±0.32 | N.A.c | 12.11±0.02 | >100 | 12.76±0.12 | N.A. | 105.58±0.18 |
2 | Salvigenin | 22.72±0.14 | 43.13±0.21 | N.A. | N.A. | >100 | 11.46±0.16 | N.A. | N.A. |
3 | Salvianolic Acid B | 10.11±0.08 | 49.83±0.27 | 45.52±0.68 | N.A. | >100 | 10.47±0.10 | 192.26±0.21 | N.A. |
4 | Salvianolic Acid A | 38.82±0.12 | 27.49±0.08 | N.A. | N.A. | 23.04±0.16 | 48.32±0.42 | N.A. | N.A |
5 | Tanshinone IIA | 32.34±0.44 | 66.26±1.18 | 14.26±0.42 | N.A. | >100 | 1.12±0.02 | 16.12±0.01 | N.A. |
6 | Dihydrotanshinone I | 64.54±0.36 | 87.19±0.23 | N.A. | N.A. | 1.50±0.02 | 0.50±0.01 | N.A. | N.A. |
7 | Tanshinone I | 31.29±0.72 | 33.01±0.86 | 42.41±0.85 | 39.82±1.16 | 38.12±0.62 | 27.67±0.04 | 174.73±0.19 | 372.86±2.47 |
8 | Carnosic Acid | 37.99±0.96 | 58.48±1.18 | 22.42±0.15 | 5.92±0.06 | 31.83±0.65 | 4.12±0.04 | 62.12±0.07 | 45.93±0.71 |
9 | Carnosol | 47.60±023 | 57.99±0.15 | 16.12±0.42 | N.A. | 11.15±0.05 | 3.92±0,03 | 26.60±0.03 | N.A. |
10 | Cryptotanshinone | 17.46±0.11 | 35.16±0.27 | 29.69±1.16 | N.A. | >100 | 28.41±0.65 | 103.05±0.11 | N.A. |
11 | Danshensu Salt | N.A. | 35.37±0.13 | N.A. | 6.20±0.08 | N.A. | 24.18±0.42 | N.A. | 48.67±0.23 |
Galanthamined | 76.08 ± 0.39 | 67.52 ± 0.41 | - | - | 5.13±0.02 | 8.19±0.12 | - | - | |
Kojic acidd | - | - | - | 69.07±0.38 | - | - | - | - | |
Thiouread | - | - | 75.14±1.34 | - | - | - | - | - |
aValues expressed are means ± S.D. of three parallel measurements and values were calculated according to negative control. were significantly different (p < 0.05)
b10µg/mL
cNot active
dStandart compounds