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. 2020 Spring;19(2):187–198. doi: 10.22037/ijpr.2020.112498.13801

Table 1.

Inhibition %, IC50 values and Equivalents of the Compounds (1-11) against AChE, BChE, Urease and Tyrosinasea.

Inhibition (%) b
IC 50 (µg/mL)
Equivalent (µg kojic acid or
thiourea activity/ mg compound)
No Compounds AChE BchE Urease Tyrosinase AChE BChE Urease Tyrosinase
1 Rosmarinic Acid 20.18±0.21 42.76±0.32 N.A.c 12.11±0.02 >100 12.76±0.12 N.A. 105.58±0.18
2 Salvigenin 22.72±0.14 43.13±0.21 N.A. N.A. >100 11.46±0.16 N.A. N.A.
3 Salvianolic Acid B 10.11±0.08 49.83±0.27 45.52±0.68 N.A. >100 10.47±0.10 192.26±0.21 N.A.
4 Salvianolic Acid A 38.82±0.12 27.49±0.08 N.A. N.A. 23.04±0.16 48.32±0.42 N.A. N.A
5 Tanshinone IIA 32.34±0.44 66.26±1.18 14.26±0.42 N.A. >100 1.12±0.02 16.12±0.01 N.A.
6 Dihydrotanshinone I 64.54±0.36 87.19±0.23 N.A. N.A. 1.50±0.02 0.50±0.01 N.A. N.A.
7 Tanshinone I 31.29±0.72 33.01±0.86 42.41±0.85 39.82±1.16 38.12±0.62 27.67±0.04 174.73±0.19 372.86±2.47
8 Carnosic Acid 37.99±0.96 58.48±1.18 22.42±0.15 5.92±0.06 31.83±0.65 4.12±0.04 62.12±0.07 45.93±0.71
9 Carnosol 47.60±023 57.99±0.15 16.12±0.42 N.A. 11.15±0.05 3.92±0,03 26.60±0.03 N.A.
10 Cryptotanshinone 17.46±0.11 35.16±0.27 29.69±1.16 N.A. >100 28.41±0.65 103.05±0.11 N.A.
11 Danshensu Salt N.A. 35.37±0.13 N.A. 6.20±0.08 N.A. 24.18±0.42 N.A. 48.67±0.23
Galanthamined 76.08 ± 0.39 67.52 ± 0.41 - - 5.13±0.02 8.19±0.12 - -
Kojic acidd - - - 69.07±0.38 - - - -
Thiouread - - 75.14±1.34 - - - - -

aValues expressed are means ± S.D. of three parallel measurements and values were calculated according to negative control. were significantly different (p < 0.05)

b10µg/mL

cNot active

dStandart compounds