Table 3. Primary Event Rate by Tertile of Percent Change in Fatty Acid From Baseline to Month 12a.
| Tertile 1b | Tertile 2 | Tertile 3 | ||||||
|---|---|---|---|---|---|---|---|---|
| No./No. (%) | Person-years | No./No. (%) | Person-years | HR (95% CI) | No./No. (%) | Person-years | HR (95% CI) | |
| Plasma EPA | ||||||||
| Omega-3 CA (<144%, 144% to 435%, >435%) | 180/1725 (10.4) | 5933 | 191/1725 (11.1) | 6035 | 1.04 (0.85-1.28) | 204/1725 (11.8) | 5951 | 1.13 (0.92-1.38) |
| Corn oil (<−28%, −28% to 10%, >10%) | 195/1735 (11.2) | 6005 | 194/1736 (11.2) | 6059 | 0.99 (0.81-1.20) | 185/1736 (10.7) | 5956 | 0.96 (0.78-1.17) |
| RBC EPA | ||||||||
| Omega-3 CA (<117%, 117% to 450%, >450%) | 185/1716 (10.8) | 5887 | 182/1717 (10.6) | 6011 | 0.96 (0.78-1.18) | 202/1716 (11.8) | 5945 | 1.08 (0.89-1.32) |
| Corn oil (<−20%, −20% to 3%, >3%) | 193/1728 (11.2) | 5980 | 194/1728 (11.2) | 6015 | 0.99 (0.82-1.22) | 186/1729 (10.8) | 5945 | 0.97 (0.79-1.19) |
| Plasma DHA | ||||||||
| Omega-3 CA (<16%, 16%-68%, >68%) | 178/1725 (10.3) | 5992 | 192/1725 (11.1) | 5989 | 1.08 (0.88-1.32) | 205/1725 (11.9) | 5937 | 1.16 (0.95-1.42) |
| Corn oil (<−17%, −17% to 6%, >6%) | 198/1735 (11.4) | 6067 | 187/1736 (10.8) | 6052 | 0.95 (0.78-1.16) | 189/1736 (10.9) | 5901 | 0.98 (0.80-1.20) |
| RBC DHA | ||||||||
| Omega-3 CA (<12%, 12%-41%, >41%) | 186/1716 (10.8) | 5960 | 189/1717 (11.0) | 5949 | 1.02 (0.83-1.25) | 194/1716 (11.3) | 5935 | 1.05 (0.86-1.28) |
| Corn oil (<−9%, −9% to 3%, >3%) | 191/1728 (11.1) | 6024 | 191/1729 (11.1) | 6052 | 1.00 (0.82-1.22) | 191/1728 (11.1) | 5864 | 1.03 (0.84-1.26) |
Abbreviations: CA, carboxylic acid formulation; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; HR, hazard ratio; RBC, red blood cell.
a
Primary cardiovascular end point rate and hazard ratio estimated using a Cox proportional hazards regression model in patients treated with omega-3 CA and corn oil, according to tertiles of percentage change in either plasma or red blood cell EPA and DHA concentrations in a post hoc exploratory analysis. Tertile range for percentage change provided for individual fatty acid species.
b
The first tertile is the reference category.