Table 4:

Concordance of reporting thresholds between AEs any grade and grade≥3 (n=141^*)

Number of patients with AE	Same threshold AE any grade and grade ≥3 (N=100)	Discordant thresholds between AE any grade and grade ≥3 (N=41)**
		Any grade	Grade ≥3
1-2 patients	39 (39%)	5 (12%)†	32 (78%)
5-10% incidence	44 (44%)	19 (46%)	9 (21%)
15-20% incidence	15 (15%)	14 (34%)	-
>=25% incidence	2 (2%)	3 (7%)	-
Total	100	41	41

^*141/209 (67%) displayed reporting thresholds for both AEs of any grade and grade ≥3. 68 trials did not disclose the threshold used for reporting either or both AEs of any grade and grade ≥3.

^**41 studies had different thresholds for AEs of any grade versus grade≥3 which are represented in both columns.

^†These 5 studies used a threshold of 2 patients to report AEs of any grade and 1 patient to report AEs grade ≥3