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. Author manuscript; available in PMC: 2020 Nov 16.
Published in final edited form as: J Am Chem Soc. 2020 May 11;142(20):9163–9168. doi: 10.1021/jacs.0c03926

Table 1.

Photocatalytic Radical Hydroarylation of Aromatics: Scope of Spirocyclic Productsa

graphic file with name nihms-1645117-t0005.jpg
a

Reaction conditions: (het)arylhalide–arene (1 equiv), P1 (5 mol %), i-Pr2NEt (3 equiv), MeCN/H2O (1:1 v/v, 15 mL/mmol), blue LEDs, 23 °C, 16 h. Isolated yields shown.

b

Reaction conducted with 10 equiv of i-Pr2NEt.

c

4:1 d.r., isolated yield of major diastereomer shown.

d

1.8:1 d.r., isolated yield of combined diastereomers shown; para-chlorobenzene dearomatization was followed by chloride solvolysis.