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. 2020 Sep 9;63(21):12929–12941. doi: 10.1021/acs.jmedchem.0c01376

Figure 4.

Figure 4

Comparison of antinociceptive effects of KGOP01 and OP-NT hybrids 7 and PK20 in the tail-flick test in mice after sc administration. Groups of mice were treated with KGOP01 (1.82 μmol/kg), 7 (2.64 μmol/kg), PK20 (5.52 μmol/kg), or saline (control), and tail-withdrawal latencies were measured at different time points after drug administration. Data are shown as means ± SEM (n = 5 to 6 mice per group). **P < 0.01 and ***P < 0.001 vs saline group; #P < 0.05, ##P < 0.01, and ###P < 0.001 hybrid 7 vs PK20; §§P < 0.01 and §§§P < 0.001 hybrid 7 vs KGOP01; two-way ANOVA with the Bonferroni post hoc test.