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. 2020 Aug 28;11(11):2087–2107. doi: 10.1021/acsmedchemlett.0c00202

Figure 8.

Figure 8

Major metabolic pathways of ketamine (HNK= Hydroxynorketamine). Major circulating metabolites of ketamine in plasma are boxed in blue. Adapted from Figure 1 with permission from Zanos P. et al. Ketamine and ketamine metabolite pharmacology. Pharmacol. Rev.2018, 70 (3), 630. Copyright 2018 ASPET.30