Table 1.
The expression (pg/mg protein) of some inflammatory cytokines or chemokines in ankle tissues of wild type and ST2-/- mice treated with vehicle (Veh, PBS) or MSU, measured by Bio-Plex multiplex immunoassays. n=5 mice/group
| Cytokines | WT+Veh | WT+MSU | St2-/-+Veh | St2-/-+MSU |
|---|---|---|---|---|
| IL-1α | 220.0±6.2 | 275.6±12.7 | 191.4±8.16 | 189.8±28.3## |
| IL-1β | 1.9±0.2 | 4.2±0.2** | 1.1±0.3 | 2.9±0.2## |
| IL-2 | 3.1±0.4 | 4.3±0.2** | 2.7±0.2 | 3.4±0.2 |
| IL-5 | 0.9±0.1 | 1.3±0.1** | 0.7±0.1 | 1.3±0.1 |
| IL-6 | 1.3±0.2 | 7.9±0.8** | 1.3±0.3 | 4.9±0.2## |
| IL-10 | 8.9±0.9 | 9.8±0.3 | 9.5±0.9 | 9.1±0.7 |
| IL-12 | 14.3±0.9 | 20.6±1.4** | 11.5±0.6 | 18.8±0.8 |
| IL-13 | 9.8±1.4 | 24.9±1.3** | 9.1±2.7 | 16.9±0.4# |
| CCL11 | 48.3±3.6 | 116.5±15.6** | 48.9±4.2 | 52.0±3.7## |
| G-CSF | 6.2±1.3 | 30.7±2.8** | 6.9±1.6 | 19.8±1.3## |
| CXCL1 | 17.4±2.4 | 76.7±7.7** | 13.7±2.2 | 27.8±3.0## |
| CCL2 | 228.6±51.3 | 1423.5±85.5** | 202.5±91.6 | 598.1±47.1## |
| CCL3 | 16.9±3.6 | 83.8±9.2** | 12.5±3.4 | 39.3±2.8## |
| CCL5 | 154.7±30.2 | 287.0±76.8** | 113.8±27.3 | 169.4±34.7 |
**p<0.01 vs. WT+Veh, #p<0.05, ##p<0.01 vs. WT+MSU. One-way ANOVA followed by Tukey`s post hoc test was used for statistical analysis.