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. 2020 Oct 25;10(26):11921–11937. doi: 10.7150/thno.46006

Figure 5.

Figure 5

High oxidative stress and high EBV lytic reactivation are positively associated with poor survival in NPC patients. (A) A high expression level of 8-OHdG is associated with poor overall survival in NPC after radiation therapy. Overall survival rates of NPC patients after radiation therapy with low (n = 63) or high (n = 66) expression levels of 8-OHdG were estimated using the Kaplan-Meier method by log-rank test (p < 0.001). (B) A high expression level of EAD is associated with poor overall survival in NPC after radiation therapy. Overall survival rates of NPC patients after radiation therapy with low (n = 64) or high (n = 65) expression levels of EAD were estimated using the Kaplan-Meier method by log-rank test (p = 0.0040). (C) Cumulative overall survival curves of the combination of 8-OHdG and EAD. NPC patients were classified into 4 groups based on 8-OHdG and EAD expression: Group 1 (n = 49): low 8-OHdG and EAD expression; Group 2 (n = 15): high 8-OHdG but low EAD expression; Group 3 (n = 14): low 8-OHdG but high EAD expression; Group 4 (n = 51): high 8-OHdG and EAD expression. (p = 0.0016). (D-F) Progression-free survival analysis according to 8-OHdG and EAD expression. (G) The stage distribution of patients with NPC according to the level of 8-OHdG. (H) The stage distribution of patients with NPC according to the level of EAD.