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. 2020 Oct 30;10(26):12204–12222. doi: 10.7150/thno.47683

Figure 5.

Figure 5

T-MSC treatment maintained proliferative potency of colon epithelium. A. FITC-dextran solutions were administered intra-gastrically, and serum FITC concentration in the acute colitis model was detected 4 h after administration. B. The proliferative potential of the remaining colon epithelium in the acute colitis model was measured by IHC staining of Ki-67 and intestinal stem cell marker Bmi1. Scale bar = 100 µm. C. Inflammatory mucosae (L, lesion) and its adjacent normal mucosae (N, normal) of IBD patients were collected and expressions of p-MAPK, AKT, p-AKT, and mTOR were measured by Western blotting. D. Colon epithelial cells in the acute colitis model were isolated and expressions of AKT, p-AKT, IGF1R, and p-IGF1R were measured by Western blotting. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.