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. 2020 Oct 30;10(26):12204–12222. doi: 10.7150/thno.47683

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Schematic diagram elucidating T-MSCs' therapeutic efficacy in colitis mice. Intravenous injection of T-MSCs showed therapeutic function in both acute and chronic DSS-induced colitis. Antibody array test indicated T-MSCs injection increased serum IGF-1 level. Further study showed elevated serum IGF-1 might originated from endogenous secretion of the liver. IGF1R-PI3K-AKT pathway in colon epithelium was upregulated after T-MSCs treatment. RNA sequencing analysis of colon samples identified DEGs that were related to cell integrity, xenobiotic metabolism, and mucous barrier. In conclusion, increased IGF-1 contributed to the integrity and regeneration of colon epithelium and promoted the recovery of chemically induced colitis in mice.