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. 2020 Oct 26;10(26):12044–12059. doi: 10.7150/thno.47901

Figure 6.

Figure 6

Lactate secreted by CAFs promotes OSCC proliferation via MCT1 expression. A) Lactate levels in CAFs medium with or without incubation of HSC3-Ctrl or HSC3-shMCT1. N=3. B) Proliferation of HSC3-Ctrl or HSC3-shMCT1 at 24 hours in CM-CAFs-Ctrl or CM-CAFs-shITGB2 with or without lactate. N=4. C) Tumor growth curves of mice injected with HSC3 cells and CAFs. N=6 mice per group. D) Tumor volumes of mice 27 days post tumor inoculation. E) Photographs of tumors in nude mice 27 days post tumor implantation. F) Representative IHC images of Ki67, ITGB2, MCT1 and LDHB in subcutaneous xenografts. G) Representative IHC images of MCT1 expression in ITGB2 low or high expression CAFs of OSCC patients. H) Correlation between ITGB2 and MCT1 expression in 34 OSCC patients. N (ITGB2-low group) =17, N (ITGB2-high group) =17.