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. 2020 Oct 26;10(26):11976–11997. doi: 10.7150/thno.50663

Table 1.

Small molecule regulators of ferroptosis

Regulators Compounds Structures Targets Model systems
Inducers Erastin graphic file with name thnov10p11976i001.jpg System Xc- B16, HT-1080 228, HT-1080, 143B, BJeLR, Calu-1 8, Islets 225, MEF, A2780 74.
Sorafenib graphic file with name thnov10p11976i002.jpg System Xc- HepG2, Hep3B, Huh7 8, Huh7, PLC/PRF5, ACHN, BxPC-3, Caki-1, HCT116, SK-MEL-3, HT-29, NCI-H460, PANC-1 71.
Sulfasalazine graphic file with name thnov10p11976i003.jpg System Xc- BJeLR, HT-1080 8, B16, HT-1080 228.
Glutamate graphic file with name thnov10p11976i004.jpg System Xc- HT-1080 8, HT-22 29.
(1S,3R)-RSL3 graphic file with name thnov10p11976i005.jpg GPX4 B16, HT-1080 228, HT-1080, 143B 8, Islets 225, BJeLR, HT-1080 55.
FIN56 graphic file with name thnov10p11976i006.jpg GPX4 BJeLR, HT-1080 72.
FINO2 graphic file with name thnov10p11976i007.jpg Iron HT-1080 229.
BAY11-7085 graphic file with name thnov10p11976i008.jpg HO-1 MDA-MB-231, MDAMB-468, MCF-7, SKBR3, A549, HuH-7, DBTRG-05MG, SKOV3 230.
t-BuOOH graphic file with name thnov10p11976i009.jpg Lipid peroxidation NIH3T3, ARPE-19 81.
Buthionine Sulfoximine graphic file with name thnov10p11976i010.jpg GSH B16, HT-1080 228, HT-1080, BJeLR, DRD 55, HCT116, A549 73.
Cisplatin graphic file with name thnov10p11976i011.jpg GSH MEF, A2780 74.
Inhibitors Ferrostatin-1 graphic file with name thnov10p11976i012.jpg Lipid ROS HT-22 29, ARPE-19 81, DAUDI, CA-46 93, HEK-293, HT22, MEF 69, HD brain-slice, oligodendrocytes, HT-1080 77, PTCs 80.
Liproxstatin-1 graphic file with name thnov10p11976i013.jpg Lipid ROS HT-22 29, HEK-293, HT22, MEF 69, DAUDI, CA-46 93, RILF 231, intestinal I/R 83, MOR 78.
SRS16-86 graphic file with name thnov10p11976i014.jpg Lipid ROS IRI 79.
Inhibitors Vitamin E graphic file with name thnov10p11976i015.jpg Lipid ROS MiaPaCa-2 232.
Trolox graphic file with name thnov10p11976i016.jpg Lipid ROS HCC1937, MDAMB-231, Hs 578T 97
Deferasirox graphic file with name thnov10p11976i017.jpg Iron AMI 28.
Deferoxamine graphic file with name thnov10p11976i018.jpg Iron ARPE-19 81, HT-22 29, DAUDI, CA-46 93, PTCs 80, MEFs 28.
Zileuton graphic file with name thnov10p11976i019.jpg 5-LOX HT22 82.
N-acetylcysteine graphic file with name thnov10p11976i020.jpg 5-LOX Neurons, IHC 187, PTCs 80.
Rosiglitazone graphic file with name thnov10p11976i021.jpg ACSL4 Intestinal I/R 83.

GPX4, glutathione peroxidase 4, HO-1, heme oxygenase 1, GSH, reduced glutathione, ROS, reactive oxygen species, 5-LOX, 5-lipoxygenase, ACSL4, acyl-Co synthetase long-chain family member 4, “NA”: not application.