Table 2.
Top 5 upstream regulators predicted to oppose TREM2 KO (group 1 genes)
| Name of regulator | Synonyms | Function | Activation Z-score | p value of overlap | Number of group 1 genes |
|---|---|---|---|---|---|
| Dexamethasone | – | Corticosteroid drug | − 2.66 | 1 × 10−38 | 195 |
| Transforming growth factor-β | TGFβ1 | Growth factor | − 2.55 | 7 × 10− 25 | 149 |
| Filgrastim | filgrastim-aafi, filgrastim-sndz | Recombinant human G-CSF drug | − 2.40 | 5 × 10− 22 | 62 |
| Immunoglobulin | Ig, antibody | Adaptive immunity | − 2.56 | 1 × 10−16 | 69 |
| Mitogen activated protein kinase 1 | MAPK1, ERK2, p42MAPK | Kinase downstream of growth factor receptors | − 2.89 | 2 × 10−16 | 50 |
Upstream regulators predicted by IPA to be inhibitory, ordered by lowest p value